Taiwan Agricultural Research Institute, Council of Agriculture, Executive Yuan--Publication-Journal of Taiwan Agricultural Research

Journal of Taiwan Agricultural Research

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Preliminary Study of Lentinus edodes Stipe Extracts on Reducing the Risk of Alzheimer’s Disease in Diabetic Animal Model

Yang, S. H., H. T. Yang, and S. C. Chiang. 2018. Preliminary study of Lentinus edodes stipe extracts on reducing the risk of Alzheimer’s disease in diabetic animal model. J. Taiwan Agric. Res. 67(4):355–364.

Preliminary Study of Lentinus edodes Stipe Extracts on Reducing the Risk of Alzheimer’s Disease in Diabetic Animal Model

Shu-Hui Yang1,*, Hui-Ting Yang2, and Shu-Chi Chiang3

Abstract

    Alzheimer’s disease (AD) is a chronic neurodegenerative disease. In this study, animal model of diabetes induced AD was studied to investigate the effect of Lentinus edodes stipe extracts (LedoStE) on improving the risk factors of AD. Resultss showed that rats fed a high-fat diet and injected lowdose streptozotocin did cause diabetes-like symptoms-eating more, drinking more and weight loss, and also led to increase of AD risk factors. Diabetes mellitus (DM) rats fed with high-dose LedoStE can effectively improve the blood parameter as well as increase insulin secretion and insulin receptor content of brain (P < 0.05), while significantly decreased the levels of AD risk factors sash as amyloid precursor proteins (APP), β-amyloid-42 (Aβ42), β-site amyloid precursor protein cleaving enzyme 1 (BACE1), advanced glycation endproducts (AGEs), and tumor necrosis factor-α (TNF-α) (P < 0.05) in brain. It also significantly increased the time (P < 0.05) to enter the open and central areas of the elevated plus-maze in DM rats taking LedoStE. From the above results, it shows that diabetic animals intake LedoStE can improve the biochemical metabolism of diabetes, which may reduce the risk of Alzheimer’s disease or delay the AD onset.

Key words: Lentinus edodes stipe extracts, Diabetes mellitus, Alzheimer’s disease, Insulin, Elevated plus-maze.


* Corresponding author, e-mail: debbie@fthes-tari.gov.tw
1 Associate Research Fellow and Head, Department of Management and Utilization, Fengshan Tropical Horticultural Experimental Branch, Taiwan Agricultural Research Institute, Kaohsiung, Taiwan, ROC.
2 Associate Professor, Department of Nutrition, China Medical University, Taichung, Taiwan, ROC.
3 Graduate Student, Department of Nutrition, China Medical University, Taichung, Taiwan, ROC.

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