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Author:Tzuhuan Hung、Weilun Qiu、Zhihu Lin、Aijung Tseng、Tungyi Lin*
Abstract:
Lung adenocarcinoma is the most common subtype of non-small cell lung cancer, characterized by high incidence and poor survival. Natural plant-derived compounds offer potential sources for anticancer drug development. This study investigated the inhibition effects and molecular mechanisms of longan flower water extract (LFWE) in H1975 lung adenocarcinoma cells. LFWE significantly reduced H1975 cell viability and induced notable morphological changes. Mechanistically, LFWE activated autophagy, evidenced by increased LC3-II/LC3-I ratios and decreased P62 levels, and promoted lysosome-mediated degradation of mutant epidermal growth factor receptor (EGFR), leading to inhibition of downstream mTOR signaling. However, LFWE showed a degree of inhibition activity toward non-malignant lung cells, potentially imposing limitations. Further studies on its safety and translational application are necessary. In summary, this study provides preliminary evidence for
exploring LFWE as a potential therapeutic strategy for lung adenocarcinoma.
Key words:Longan flower water extract, Lung adenocarcinoma, Autophagy, EGFR
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Taiwan Agricultural Research
ISSN: 2790-086X
Vol. 75, No.1 (2026)
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