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Effect of Tremella Polysaccharides Nonwoven Dressing on Healing of Surgical Wounds of Rats
Measurement of residual wound area of rat skin after covered Alg-NC (negative control) for 3 days. (A) A photograph showing the wounded area, (B–D) Photographs of wound residual area taken by CCD camera. Note the wound residual area (%) was calculated by the area of wound (C) and divided by total excised area (2 cm × 2 cm) (D) and then multiplied with 100.
Measurement of residual wound area of rat skin after covered Alg-NC (negative control) for 3 days. (A) A photograph showing the wounded area, (B–D) Photographs of wound residual area taken by CCD camera. Note the wound residual area (%) was calculated by the area of wound (C) and divided by total excised area (2 cm × 2 cm) (D) and then multiplied with 100.

Author:Kun-Chao Chen, Jhaol-Huei Wu, Chung-Hsin Chen, Jiunn-Wang Liao, Chan-Yi Yang, and Shu-Hui Yang*

Abstract:

    Some commercial products used as wound dressing in clinics are made of natural polysaccha-rides which are biodegradable and biocompatible.  Polysaccharides extracted from fruiting bodies of Tremella fuciformis are nature polymers with moisturizing and anti-infammatory properties.  The ob-jective of this study was to determine effects of the Tremella-polysaccharide non-woven product (Tp-nonW) as wound dressing on healing of surgical wounds of rats.  Results showed that wound dressing with Tp-nonW or Kal-PC (a commercial product Kaltostat® made of Calcium/Sodium Alginate and used as positive control) signifcantly (p < 0.05) decreased the wound area of rats.  Compared to the treatment of wound dressing of Alg-NC (a commercial product made of Sodium Alginate and used as negative control), the healing area of wounds covered with Tp-nonW for 10 and 14 days increased by 20 and 49.2% respectively.  Results of the histopathological study showed that the score of regrowth tissues from wounded skin was 5.8 and 5.4 for the treatment of Kal-PC and Tp-nonW, respectively, compared to the score of 4.6 for the negative control Alg-NC, but the difference among these three treatments was statistically insignifcant (p > 0.05).  This study suggests that Tremella-polysaccharide non-woven dressing (Tp-nonW) has wound healing properties on rats and it may warrant further stud-ies in human clinic trials.

Key words:Tremella fuciformis, Polysaccharides nonwoven, Wound dressing, Animal model

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Journal of
Taiwan Agricultural Research
Vol. 73, No.1 (2024) ISSN: 2790-086X Vol. 73, No.1 (2024)
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